Safety Data Sheet

ACETONE SODIUM BISULFITE

Revision date :
Version : 3.0	NUMBER

1	IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1	Product identifiers
	Chemical Name			Acetone Sodium Bisulfite
	CAS NO.			540-92-1
1.2	Relevant identified uses of the substance or mixture and uses advised against
	ASB is used as anti-oxidant, preservative (reducing agent) in several pharmaceuticals such as Procaine HCl Injection, Dibucaine 1% Ointment. ASB is also used in Mepivacaine hydrochloride Injection,.Pentazocine Lactate Injection, Bupivacaine Hydrochloride Injection, and Epinephrine Injection. ASB along with Persulfate are widely used as Redox Pair (initiator-inhibitor)combination in both emulsion based and emulsion free, resins.
	Details of the supplier of the safety data sheet
	COMPANY			POLYMER ADD (THAILAND) CO., LTD. 106, Chalaremprakiat, Lor 9, Soi 22, Yak 5,Nongbon, Prawet,Bangkok Bangkok - 10250 Thailand Telephone : 0804531391 Email - contact@polymeradd.co.th
2	HAZARDS IDENTIFICATION
2.1	Classification of the substance or mixture
	Physical and Chemical Hazards			No data available
	Human Health			No data available
	Environment			No data available
	No data available
2.2	Labelling according Regulation (EC) No 1272/2008 [CLP]
	Label elements			No data available
	Hazard statement(s)			No data available
	Precautionary statement(s)			No data available
	According to European Directive 67/548/EEC as amended			No data available
2.3	Other hazards			None
3	COMPOSITION/INFORMATION ON INGREDIENTS
3.1	Substances
	Component
	Chemical Name		Acetone Sodium Bisulfite
	CAS NO		540-92-1
	EC Number		208-761-2
	Molecular Formula		C3H7NaO4S
	Molecular Weight		162.14 g/mol
	Concentration		Min. 98%
4	FIRST AID MEASURES
4.1	Description of first aid measures
	General advice
	Consult a physician. Show this safety data sheet to the doctor in attendance
	If inhaled			If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
	In case of skin contact			Wash off with soap and plenty of water. Consult a physician.
	In case of eye contact			Flush eyes with water as a precaution
	If swallowed			Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician
4.2	Most important symptoms and effects, both acute and delayed
	To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
4.3	Indication of any immediate medical attention and special treatment needed
	No data available
5	FIREFIGHTING MEASURES
5.1	Extinguishing media
	Suitable extinguishing media			Use water spray, carbon dioxide, dry chemical powder or appropriate foam.
5.2	Special hazards arising from the substance or mixture			Emits toxic fumes under fire conditions
5.3	Advice for firefighters			Wear self contained breathing apparatus and protective clothing to prevent contact with skin and eyes
5.4	Further information			No data available
6	ACCIDENTAL RELEASE MEASURES
6.1	Personal precautions protective equipment and emergency procedures
	Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust.
6.2	Environmental precautions
	Do not let product enter drains
6.3	Methods and materials for containment and cleaning up
	Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal
6.4	Reference to other sections
	For disposal see section 13
7	HANDLING AND STORAGE
7.1	Precautions for safe handling
	Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Norma
7.2	Information about protection against explosions and fires
	No data available
7.3	Conditions for safe storage including any incompatibilities
	Store in cool place. Keep container tightly closed in a dry and cool place.
7.4	Specific end use(s)
	None
8	EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1	Control parameters
	Appropriate engineering controls
	Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
	Eye/face protection
	Safety glasses with side-shields .Use equipment for eye protection teHandle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. sted and approved under appropriate government standards.
	Hands protection
	Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
	Skin protection
	Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
	Body Protection
	Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace
	Respiratory protection
	Use respirators and components tested and approved under appropriate government standards.
	Control of environmental exposure
	None
9	PHYSICAL AND CHEMICAL PROPERTIES
	a)Appearance			Form: Crystalline powder Colour : White
	b)Odour			Odourless
	c)Odour Threshold			No data available
	d)pH (% solution in water)			No data available
	pH			4-5
	e)Melting point/freezing point			Above 300⁰C
	f)Initial boiling point and boiling range			No data available
	g)Flash point			No data available
	h)Evaporation rate			No data available
	i)Flammability (solid or gas)			No data available
	j)Upper/lower flammability or explosive limits			No data available
	k)Vapour pressure			No data available
	l)Vapour density			No data available
	m)Relative density			1.488 g/cm3
	n)Water solubility			10% solution is clear
	o)Partition coefficient: n-octanol/water			No data available
	p)Autoignition temperature			No data available
	q)Decomposition temperature			No data available
	r)Viscosity			No data available
	s)Explosive properties			No data available
	t)Oxidizing properties			No data available
9.2	Other safety information
	Bulk Density			No data available
10	STABILITY AND REACTIVITY
10.1	Reactivity			No data available
10.2	Chemical stability			Stable
10.3	Possibility of hazardous reactions			Will not occur
10.4	Conditions to avoid			No data available
10.5	Incompatible materials			Strong oxidizing agents, Acids.
10.6	Hazardous decomposition products			Carbon monoxide, Carbon dioxide, Sulfur oxides.
11	TOXICOLOGICAL INFORMATION
11.1	Information on toxicological effects
	Acute toxicity			LD50 Intraperitoneal Mouse >1 GM/KG
	Acute oral toxicity			No data available
	Acute Inhalation toxicity			No data available
	Acute dermal toxicity			No data available
	Acute Irritation / corrosion toxicity			No data available
	Skin corrosion/irritation			Causes skin irritation.
	Serious eye damage/eye irritation			Causes eye irritation
	Respiratory or skin sensitization			Material is irritating to mucous membranes and upper respiratory tract.
	Germ cell mutagenicity			No data available
	Carcinogenicity			No data available
	IARC			No data available
	Reproductive toxicity			No data available
	Specific target organ toxicity - single exposure			No data available
	Specific target organ toxicity - repeated exposure			No data available
	Signs and symptoms of exposure			To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
	Route of exposure			No data available
	Aspiration hazard			To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
	Inhalation			Material is irritating to mucous membranes and upper respiratory tract.
	Ingestion			May be harmful by ingestion.
	Skin			Causes skin irritation
	Eyes			Causes eye irritation
	RTECS			TZ6550000
12	ECOLOGICAL INFORMATION
12.1	Toxicity			No data available
	Toxicity to fish			No data available
	Toxicity to daphnia and other aquatic invertebrates			No data available
	Toxicity to Algae/Aquatic plants			No data available
	Toxicity to microorganisms			No data available
12.2	Persistence and degradability
	Biodegradation
	No data available
12.3	Bio accumulative potential			No data available
12.4	Mobility in soil			No data available
12.5	Results of PBT and vPvB assessment			No data available
12.6	Other adverse effects			No data available
13	DISPOSAL CONSIDERATIONS
13.1	Waste treatment methods
	Product
	Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this
	Contaminated packaging
	Dispose of as unused product
14	TRANSPORT INFORMATION
14.1	UN number
	ADR/RID		IMDG		IATA
	-		-		-
14.2	UN proper shipping name
	ADR/RID		IMDG		IATA
	Not dangerous goods		Not dangerous goods		Not dangerous goods
14.3	Transport hazard class(es)
	ADR/RID		IMDG		IATA
	-		-		-
14.4	Packaging group
	ADR/RID		IMDG		IATA
	-		-		-
14.5	Environmental hazards
	ADR/RID		IMDG Marine pollutant		IATA
	-		-		-
14.6	Special precautions for user			None
15	REGULATORY INFORMATION
	This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1	Safety health and environmental regulations/legislation specific for the substance or mixture
	no data available
15.2	Chemical Safety Assessment
	no data available
16	OTHER INFORMATION
	See under section 2
	See under section 2
	Further information
	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Dr J Pharmachem (India) and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.jpharmachem.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale. Month of Revision :- March 2027 :-